Table 3 Hazard ratios (HR) of mortality in 1024 patients on ART
Determinants | Univariate analysis | Multivariate analysisf | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Place of ART a | ||||
Kailali Districb (ref.) | 1.00 | |||
Kanchanpur Districtb | 2.03 (1.10 – 3.73) | 0.023 | ||
Doti Districtc | 1.93 (1.24 – 3.00) | 0.004 | ||
Achham Districtc | 1.71 (1.05 – 2.78) | 0.031 | ||
Sex | ||||
Female (ref.) | 1.00 | 1.00 | ||
Male | 5.40 (3.37 – 8.65) | <0.001 | 4.55 (2.43 – 8.51) | <0.001 |
Age groups (years) | ||||
15- 32 years (ref.) | 1.00 | |||
33- 40 years | 1.66 (1.04 – 2.64) | 0.033 | ||
>40 years | 1.93 (1.19 – 3.14) | 0.008 | ||
Education | ||||
Illiterate (ref.) | 1.00 | |||
Literate | 1.45 (0.96 – 2.17) | 0.075 | ||
Performance scale | ||||
Normal (ref.) | 1.00 | 1.00 | ||
Bedridden <50% | 4.54 (2.99 – 6.88) | <0.001 | 2.05 (1.19 – 3.52) | 0.010 |
Bedridden >50% | 5.53 (3.45 – 8.87) | <0.001 | 3.41 (1.67 – 6.98) | 0.001 |
Bodyweight (Kg)d | 1.02(1.01 – 1.05)g | 0.048 | 1.04(1.01 – 1.07)g | 0.010 |
WHO clinical stage | ||||
Stage I or II (ref.) | 1.00 | 1.00 | ||
Stage III | 4.39 (2.25- 8.55) | <0.001 | 2.96 (1.31- 6.69) | 0.009 |
Stage IV | 8.85 (4.43-17.66) | <0.001 | 3.28 (1.30- 8.29) | 0.012 |
CD4 count (cells/mm 3)d | 0.99 (0.98- 0.99) | <0.001 | ||
Drug toxicity/side effects | ||||
No (ref.) | 1.00 | |||
Yes | 1.45 (0.96- 2.19) | 0.078 | ||
Active TB during treatment | ||||
No (ref.) | 1.00 | |||
Yes | 1.73 (1.15- 2.61) | 0.009 | ||
ART regimen e | ||||
d4T/3TC/NVP (ref.) | 1.00 | |||
d4T/3TC/EFV | 0.90 (0.39- 2.07) | 0.803 | ||
ZDV/3TC/NVP | 0.49 (0.31- 0.77) | 0.002 | ||
ZDV/3TC/EFV | 0.97 (0.54- 1.73) | 0.907 | ||
ART regimen change | ||||
No (ref.) | 1.00 | |||
Yes | 1.37 (0.94- 2.00) | 0.10 | ||